# Key Points from IRC Discussions

• Participants discussed nootropic experimentation, with users reporting experiences with modafinil and plans to try noopept with alpha-GPC, while emphasizing the importance of quality testing compounds using GC/MS and NMR to avoid contaminated products.

• Diablo-D3 shared research on the relationship between orexin-producing cells, leptin inhibition, and HCN channels, highlighting the connection between metabolism and sleep regulation mechanisms.

• Kanzure presented research on thalamic relays in cognition and motor cortex mapping, including how electrical stimulation can evoke complex, meaningful actions in primates.

• The group discussed a paper showing dissociation between mental fatigue and motivational states during prolonged mental activity, suggesting these are separable phenomena in cognitive tasks.

• Several papers on cerebellar networks revealed extensive non-motor connections beyond traditional motor control functions, including links to prefrontal cortex, posterior parietal cortex, and basal ganglia.

• Evidence was shared showing evolutionary expansion of non-motor domains in the cerebellar cortex of great apes and humans, mirroring prefrontal cortex enlargement.

• Participants discussed unexpected brain-body connections through papers like "The motor cortex communicates with the kidney" and the use of neurotropic viruses as transneuronal tracers for mapping multisynaptic pathways.

• The conversation included extensive discussion of Sci-Hub and Library Genesis as academic paper access tools, with kanzure sharing that Sci-Hub was accessible again at sci-hub.cc and through various mirrors including a Tor hidden service.