# Key Points from #hplusroadmap IRC Discussions

• A major Ethereum hack resulting in $60 million theft prompted controversial intervention by the Ethereum Foundation, which decided to implement system changes to roll back the theft, causing significant division in the cryptocurrency community.

• Discussion of a new Human Genome Project initiative focused on synthetic human genome creation using enzymatic approaches, with assembly identified as a critical bottleneck despite advances in parallelized oligonucleotide synthesis.

• Technical limitations in DNA synthesis were explored, particularly how pick-and-place operations for 100 million spots remain time-consuming, and how microfluidic approaches face routing challenges with high valve count designs.

• Several biotechnology companies were highlighted, including Recombinetics (genetically modified pig disease models), Editas Medicine, enEvolv (engineered microorganisms), and eGenesis (xenotransplantation research).

• A technical discussion about polyphonic music transcription revealed that converting audio files (MP3/WAV) to MIDI format remains "a substantially unsolved problem" for polyphonic cases, despite the existence of various algorithms.

• A user shared information about a 3D printer equipped with a magnetometer designed to visualize magnetic fields, linking to a relevant Hackaday article.