# Key Points from IRC Discussion

• Researchers shared and discussed molecular dynamics simulation videos of RNA polymerase and transcription processes, examining structural similarities between DNA polymerase and DNA ligase enzymes, with references to specific Protein Data Bank structures.

• A novel concept was proposed for controlling DNA polymerase activity through electrical resistance testing, suggesting that multiple conformational shape changes could be achieved using azobenzene amino acids placed in different locations within the polymerase.

• Participants debated approaches to genome synthesis, contrasting enzymatic optimization versus physical parallelization with multiple reaction chambers, while noting that current polymerase speeds (1000 nt/sec) are too slow for efficient genome printing.

• The conversation highlighted resources like Biohack Academy's documentation repositories and discussed the future of OpenWetWare.org, emphasizing the importance of preserving scientific content that has been referenced in academic publications.

• Researchers shared papers and patents related to photoswitchable click amino acids and electronic polymerase-based DNA sequencing, while discussing visualization tools for molecular structures that could reduce visual clutter when examining protein-DNA interactions.

• A participant mentioned developing "bionet" with sandboxed versioned web apps stored in a database, addressing the problem of disappearing bioinformatics tools and the poor state of biology forums and online resources.