# Key Technical and Conceptual Points from #hplusroadmap

• GitHub's new support for STL (3D model) diffs was highlighted through a shared example of "connection points" implementation in a Python-BRL-CAD-TCL project, demonstrating advances in collaborative 3D modeling workflows.

• Neuroscience research was discussed, particularly MAPseq technology for high-throughput mapping of single neuron projections using barcoded RNA sequencing, representing cutting-edge approaches to neural connectomics.

• A patent application from Molecular Assemblies was analyzed, describing novel methods for enzymatic synthesis of DNA/RNA using specially designed nucleotide analogs in aqueous environments without templates, potentially advancing synthetic biology capabilities.

• Attention Schema Theory by Graziano was evaluated, with participants finding value in its model of how the brain constructs representations of its own attention processes, contributing to discussions on consciousness and cognitive science.

• Peter Rothman's self-experimentation with thyroid or thymus regeneration was mentioned, indicating ongoing interest in practical biohacking approaches to longevity and regenerative medicine.

• An online LLVM-based C++ REPL tool (http://fiddle.jyt.io/) was shared, providing a resource for rapid code testing and development in systems programming.

• A "p2p yak shaving/yak trading" concept was proposed, suggesting a novel approach to distributed collaboration where preliminary tasks could be exchanged between peers to improve overall productivity in complex projects.