# Summary of ##hplusroadmap IRC Log (Nov 17, 2016)

* A breakthrough in CRISPR/Cas9 technology was shared: "In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration" which allows for robust DNA knock-in in both dividing and non-dividing cells, with therapeutic potential demonstrated in a rat model of retinitis pigmentosa.

* Research on sleep regulation was discussed, highlighting mutations in the Sik3 protein kinase and sodium leak channel NALCN that impact total sleep duration and REM sleep duration by increasing the excitability of REM sleep-inhibiting neurons.

* A study on cannabinoid effects on memory was shared, revealing that mitochondrial CB1 receptors regulate memory processes through modulation of mitochondrial energy metabolism via G-protein signaling pathways.

* SpaceX's FCC application for over 4,000 internet satellites was noted, indicating significant progress in their global satellite internet constellation project.

* A paper titled "The mathematics of science's broken reward system" was shared, likely discussing quantitative analysis of problems in academic incentive structures.

* Advanced imaging technology was mentioned: "Tracking the ultrafast motion of a single molecule by femtosecond orbital imaging," representing cutting-edge capabilities in molecular visualization.