# Key Points from IRC Discussion

• A science fiction concept from the Heechee Saga was discussed, where an advanced civilization attempts to alter universal physics by triggering a big crunch followed by a new big bang with more favorable physical laws.

• Several significant AI research papers were shared, including work on CNN backward passes using generative models, deep learning with segregated dendrites (demonstrating multi-compartment neurons can achieve deep learning), and meta-learning approaches in "Learning to reinforcement learn."

• Bioengineering research on improving photosynthesis was highlighted, showing a 15% productivity increase by accelerating plants' recovery from photoprotection, addressing the evolutionary puzzle of why plants haven't naturally optimized photosynthetic efficiency.

• Light-controllable protein technologies were discussed, including a method using Dronpa proteins to cage Cre recombinase (creating proteins that can be activated by light) and techniques for regulating protein stability with light exposure.

• The conversation included skeptical analysis of GDF-11 as an anti-aging treatment, questioning claims by a self-experimenter turned entrepreneur, with concerns about dosing discrepancies, protein quality, and contradictory research suggesting it might suppress neurogenesis.

• Anti-aging research was discussed, including carbonic anhydrase II as a potential longevity target based on C. elegans studies, and ellagic acid (found in pomegranates) as a carbonic anhydrase inhibitor with demonstrated effects on reducing wrinkles.