# Summary of IRC Log from #hplusroadmap (November 26, 2016)

* Research on sleep modification was discussed, including genetic modifications for resistance to sleep deprivation, particularly the TNFα G308A polymorphism, as documented in the DIY H+ Wiki.

* Several scientific papers on sleep manipulation were shared, including "N-acetylcysteine inhibits muscle fatigue in humans" and research showing that optogenetic activation of dopamine neurons in the ventral tegmental area can induce reanimation from general anesthesia.

* A genome-wide association study involving over 119,000 individuals was mentioned, which identified thirteen morningness and two sleep duration loci, including PAX8 and VRK2 genes.

* There was discussion about the potential for megabase-scale genome assembly in single cells, with speculation about experimental approaches involving Gibson assembly and careful selection processes.

* Participants critically analyzed NASA's EM Drive paper, with debate about whether the observed thrust effect might be due to thermal expansion rather than a new propulsion mechanism, and criticism of the experimental methodology.

* A connection between circadian rhythm disruption and cancer development was noted, with a link shared to research on the role of melatonin in cancer treatment.