# Key Points from #hplusroadmap IRC Discussion

• Kanzure outlined a proof-of-publication client-side validation scheme for cryptocurrency where transaction validity depends on specific merkle tree locations rather than output hashes, preventing double-spends within the same block.

• Research on transthyretin amyloid was discussed, noting it's the primary cause of death in supercentenarians (110+), with Pentraxin Therapeutics developing a therapy to clear this age-related protein accumulation.

• George Church's innovative approach to connectomics was highlighted, focusing on DNA sequencing rather than optical scanning for brain mapping, as detailed in his "Rosetta brains" paper on molecularly-annotated connectomics.

• Participants contrasted Kurzweil's "science promotion" approach with Church's hands-on research, arguing that writing about future technology without actively developing it is less productive than direct scientific contribution.

• A technical discussion addressed the challenge of uneconomical cryptocurrency UTXOs (when transaction fees exceed their value), proposing a hard-fork solution to aggregate small outputs into multisig transactions.

• Kanzure advocated viewing biological systems as existing molecular nanotechnology, recommending researchers focus on proteins or DNA origami rather than theoretical nanobots, sharing resources from his nanoengineer repository.

• Advanced imaging techniques were discussed, including "Diffusible iodine-based contrast-enhanced computed tomography" (diceCT) for high-resolution 3D imaging of soft tissues, alongside an open ultrasound project demonstrating DIY medical imaging possibilities.