# Summary of #hplusroadmap IRC Log (Jan 27, 2017)

* Discussion about open source biology, with kanzure noting that the patent system needs to be dismantled first, as open source is primarily concerned with copyright law rather than patents.

* Inscopix was mentioned, a company with the tagline "Cracking the neural code with Technology, Training, and Partnership" focused on neuroscience technologies.

* Multiple articles from anti-agingfirewalls.com were shared, including pieces on DNA methylation, inflammation, NAD metabolism, and a "Grand Unified Theory of Biology, Health and Aging."

* Research on brain-region-specific organoids was discussed, including developments in forebrain, midbrain, hypothalamic, and retinal organoids, with particular interest in the lack of auditory and visual cortex organoids.

* A study showing that deletion of PTEN generates larger and folded cerebral organoids was highlighted, suggesting potential for more complex brain tissue development in vitro.

* The role of DNA methylation in aging was examined, noting that complete deletion of DNMT1 (a DNA methyltransferase) is embryonic lethal in mice, raising questions about potential low-efficacy mutations.

* Discussion of irisin (a protein encoded by the FNDC5 gene) and its potential effects on fat cells, with speculation about its ability to convert fat stem cells into bone-forming cells.