# Key Points from IRC Log

• A discussion about NMDA positive allosteric modulators occurred, with a question about whether they could replace current neuroleptics, showing interest in novel approaches to psychiatric medications.

• DARPA's "Radio Bio" program was shared, which aims to investigate whether purposeful electromagnetic wave signaling between biological systems exists, prompting skepticism from some participants who compared it to research on psychic phenomena.

• Several significant papers on protein design were shared, including "Designing novel protein backbones through digital evolution" and research on peptoid nanosheets exhibiting new secondary-structure motifs, highlighting advances in protein engineering.

• Research on genetic factors in exceptional longevity was discussed, including a 2014 paper on exome sequencing of individuals with familial exceptional longevity, with specific mention of mutations in apolipoprotein B and hypobetalipoproteinemia.

• A paper on "Autophagy-mediated longevity is modulated by lipoprotein biogenesis" was shared, connecting autophagy mechanisms to longevity through lipoprotein pathways.

• Information about TET2 and DNMT3A genes was discussed in relation to hematopoietic stem cell self-renewal and potential compensatory mechanisms for age-related immune system decline in exceptionally long-lived individuals.

• A GitHub commit was shared adding information about alleles associated with exceptional episodic memory to a wiki on genetic modifications, indicating community interest in cognitive enhancement genetics.

• Deep learning library popularity statistics were shared via Twitter, showing the relative GitHub activity across different frameworks, providing insight into trends in AI development tools.