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| Diablo-D3 | .title http://www.impactaging.com/papers/v6/n9/full/100690.html | 04:38 |
|---|---|---|
| yoleaux | Reversal of cognitive decline: A novel therapeutic program - AGING Journal | 04:38 |
| JayDugger | That's a rather long list of approaches in Table 1 of that paper. | 04:39 |
| JayDugger | I'd call it a shotgun approach, but they seem to have chosen more carefully than that. | 04:40 |
| Diablo-D3 | No, I don't think it is | 04:40 |
| Diablo-D3 | In fact, thats actually rather similar to what I've been trying as an autism cure | 04:41 |
| Diablo-D3 | It enhances my brain function, it does not cure autism | 04:41 |
| lkjhfr | it's basically: don't eat shit | 04:44 |
| JayDugger | We seem to talking past each other here. Twenty-five rows appear in Table 1. I called that a long list, and I said nothing about its efficacy. | 04:44 |
| Diablo-D3 | JayDugger: several of them are parts of the same thing | 04:44 |
| JayDugger | No, they have some non-dietary approaches in that list: dietary supplements and treating sleep apnea. Neither of those exclude items of diet. | 04:45 |
| JayDugger | Yes, some of the 25 do seem to overlap. | 04:45 |
| Diablo-D3 | what I find weird is | 04:45 |
| Diablo-D3 | "CoQ or ubiquinol, α-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine" | 04:45 |
| JayDugger | I'll have to read the whole thing to understand that overlap better. | 04:45 |
| Diablo-D3 | is just one row | 04:45 |
| JayDugger | By the way, thank you for posting a link to that paper. | 04:45 |
| Diablo-D3 | you know how many fucking vitamins I have to take to do that? | 04:46 |
| Diablo-D3 | just that fucking one row? | 04:46 |
| JayDugger | Um...is that a trick question? | 04:46 |
| Diablo-D3 | and I dont even take that whole row | 04:46 |
| JayDugger | It depends on where you shop and what you buy, obviously. | 04:46 |
| JayDugger | Even more flippantly, if it prevents or treats A.D., do you really care? | 04:47 |
| JayDugger | What's ALCAR in this context? | 04:47 |
| Diablo-D3 | Acetyl-L-carnitine | 04:47 |
| JayDugger | If you want a number for the answer though,---oh, duh. Thanks. | 04:47 |
| Diablo-D3 | the thing is, almost all of that | 04:47 |
| Diablo-D3 | I take for mitocondrial improvement | 04:48 |
| Diablo-D3 | like, that entire list | 04:48 |
| Diablo-D3 | I know _exactly_ what they were doing | 04:48 |
| JayDugger | The number would be three or four different supplements, without looking at the labels. | 04:48 |
| Diablo-D3 | JayDugger: well lets see here, Ill tell you what I take currently | 04:48 |
| JayDugger | No, I think that's only part of it. | 04:48 |
| Diablo-D3 | "Optimize fT3, fT4, E2, T, progesterone, pregnenolone, cortisol" | 04:49 |
| Diablo-D3 | that part I find weird | 04:49 |
| JayDugger | I don't know of any effects on mitochondria from MCT oil / cococnut oil, but I'd happily learn better. | 04:49 |
| JayDugger | Yeah, that line goes over my head. | 04:49 |
| Diablo-D3 | MCT is extremely interesting | 04:50 |
| JayDugger | Do you recognize fT3 fT4, and E2 in this context? | 04:50 |
| JayDugger | I'll guess T means testosterone. | 04:50 |
| JayDugger | Do fTN mean free Testosterone N? | 04:50 |
| JayDugger | Estrogen 2 = E2? | 04:50 |
| Diablo-D3 | Not sure about those | 04:51 |
| JayDugger | For all I know those might be common lab codes for blood analysis. | 04:51 |
| lkjhfr | ft3 and ft4 is thyroid | 04:51 |
| JayDugger | Optimize hygiene? What's that? | 04:52 |
| JayDugger | Ah...thanks. | 04:52 |
| Diablo-D3 | well, taking a shower feels nice | 04:52 |
| Diablo-D3 | maybe feeling nice is the cure for this | 04:52 |
| lkjhfr | e2 is estradiol | 04:52 |
| JayDugger | Heh, heh. True enough, but I doubt it. | 04:52 |
| JayDugger | fT3, free triiodothyronine; fT4, free thyroxine from under the table. | 04:53 |
| JayDugger | I think I'll stop speculating until after I finish reading. Less embarrassing. | 04:53 |
| lkjhfr | it's mostly: don't eat shit | 04:53 |
| Diablo-D3 | but yeah, MCT shuttles fats into your mitocondria | 04:53 |
| JayDugger | Oh? I didn't know that. | 04:53 |
| Diablo-D3 | Im simplifying it, and I expect to be yelled at | 04:54 |
| JayDugger | So they improve mitochondria function and encouraged autophagy. | 04:54 |
| Diablo-D3 | yes | 04:54 |
| JayDugger | And ketogenesis. | 04:54 |
| Diablo-D3 | now what Ive done | 04:55 |
| Diablo-D3 | in my research | 04:55 |
| Diablo-D3 | which apparently does fucking work | 04:55 |
| Diablo-D3 | just not for me | 04:55 |
| Diablo-D3 | Ive gone strict paleo | 04:55 |
| Diablo-D3 | no grains, no refined sugars, no shit | 04:55 |
| lkjhfr | Diablo-D3, what do you mean by taking vitamins? | 04:55 |
| Diablo-D3 | Ive increased protein and fat intake | 04:56 |
| JayDugger | What effect did you seek but not get? | 04:57 |
| Diablo-D3 | oh, cure for autism | 04:57 |
| Diablo-D3 | I was suspecting it was either a mitocondrial disorder or a problem with something in the dopamine system somewhere | 04:59 |
| lkjhfr | also: what do you mean by increasing fat intake? | 04:59 |
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| Diablo-D3 | literally, eating fat | 05:00 |
| Diablo-D3 | anyhow, the list of shit I take | 05:00 |
| lkjhfr | but, SFAs, or PUFA? | 05:00 |
| Diablo-D3 | no, I mean fat | 05:00 |
| Diablo-D3 | on meat | 05:00 |
| Diablo-D3 | fatty cuts of meat | 05:00 |
| lkjhfr | SFA | 05:00 |
| Diablo-D3 | the skin and fat on chicken | 05:00 |
| Diablo-D3 | none of this low fat FDA nonsense | 05:00 |
| lkjhfr | that's saturated fatty acids, and noone said that those chicken are fed well | 05:01 |
| JayDugger | Ah... that provides some context. | 05:02 |
| Diablo-D3 | anyhow, vitamin D, ubiquinol, biopqq, beta carotine, alpha carotine, luetein, zeaxanthin, lycopene, astaxanthin, dmae... | 05:02 |
| Diablo-D3 | vitamin E in the forms of alpha, beta, gamma, and delta tocopherols, and the same for tocotrienols | 05:03 |
| Diablo-D3 | vitamin C, mixed bioflavonoids | 05:04 |
| Diablo-D3 | alcar, arginine, alpha lipolic acid | 05:04 |
| Diablo-D3 | vitamin b1, 2, 3, 5, 6, 7, 9, 12, | 05:06 |
| JayDugger | optimize "oral" hygiene--what's an electric flosser? | 05:06 |
| Diablo-D3 | 6 as pyridoxal 5-phosphate, folate as methyl-tetrahydrofolate | 05:07 |
| Diablo-D3 | choline, paba | 05:07 |
| Diablo-D3 | k1, k2, calcium, iodine, magnesium, zinc, selenium, copper, maganese, chromium, molybdenum, potassium | 05:08 |
| lkjhfr | but... you were taking pills with those? | 05:08 |
| Diablo-D3 | and north of 2000mg of EPA, and north of 1000mg DHA. | 05:08 |
| Diablo-D3 | lkjhfr: yup. | 05:08 |
| lkjhfr | but, you know that all those are basically components or food | 05:09 |
| lkjhfr | of food | 05:09 |
| Diablo-D3 | was interested in the amounts. | 05:09 |
| JayDugger | Pills are easier to count and handle than food. | 05:10 |
| lkjhfr | but just then, he could replace the chicken with a bottle of oil and soy protein isolate | 05:11 |
| JayDugger | Yes. Not for everyone, I admit, even if one has the luxury of ignoring the social aspects of eating. | 05:11 |
| lkjhfr | no, i mean: he didn't. he controled everything besides that chicken. | 05:12 |
| JayDugger | Oh. Sorry, my misunderstanding. | 05:12 |
| Diablo-D3 | I dont eat a lot of chicken =P | 05:13 |
| Diablo-D3 | I eat mostly beef and pork | 05:13 |
| Diablo-D3 | and until they fucked beef pricing it was mostly beef | 05:14 |
| lkjhfr | Diablo-D3, didn't you forget about sodium though? | 05:24 |
| lkjhfr | the less processed the food, and the more fat in it, the more salt you need to add | 05:24 |
| Diablo-D3 | lkjhfr: yes, I eat unrestricted sodium | 05:25 |
| lkjhfr | so, you thought you'd feel better if you ate all the vitamins and changed the macronutrient proportions, and it didn't work? | 05:26 |
| Diablo-D3 | lkjhfr: vaguely | 05:29 |
| Diablo-D3 | lkjhfr: I take almost everything the body uses to make almost every neurotransmitter | 05:33 |
| lkjhfr | haha | 05:33 |
| Diablo-D3 | whatever autism is, its not a shortage of the ingredients. | 05:33 |
| lkjhfr | i am undernourished, and i did try doing this stuff with vitamins, but i chose natural sources, and it did make me feel a bit better, it even changed my perception a bit | 05:36 |
| Diablo-D3 | sufficient amounts of some things, large amounts of others, doesnt fix it | 05:36 |
| Diablo-D3 | taking everything I could think of to boost mitochondria performance | 05:37 |
| Diablo-D3 | didnt fix it | 05:37 |
| lkjhfr | i have like, narrow vision usually, but at those times that i tried eating better, my perception was wider | 05:38 |
| lkjhfr | and i ate, like, 200% of the vitamins | 05:39 |
| lkjhfr | of the rda or whatever is it called | 05:39 |
| Diablo-D3 | I can stay alert longer, I can think harder, my exercise performance has increased way more than I imagined, and Im building muscle faster than I ever have | 05:40 |
| lkjhfr | then what didn't work | 05:41 |
| Diablo-D3 | Still autistic. | 05:42 |
| lkjhfr | did you tried to pretend to not be autistic? | 05:43 |
| Diablo-D3 | Heh, doesn't work that way. | 05:43 |
| lkjhfr | so you haven't tried? | 05:44 |
| Diablo-D3 | You mean lying out my ass? | 05:44 |
| lkjhfr | no, like, acting out | 05:44 |
| Diablo-D3 | I am not a gifted liar, something that comes natural to most people | 05:44 |
| lkjhfr | but that's what kids do | 05:45 |
| lkjhfr | at early age, kids socialize by acting | 05:45 |
| Diablo-D3 | Yes, but it requires their mirror neurons to functio | 05:46 |
| Diablo-D3 | They need to use their innate ability to read other people | 05:46 |
| lkjhfr | so, science basically says that you can't stop being autistic? | 05:49 |
| Diablo-D3 | Yes, and I believe science just isn't there yet | 05:49 |
| Diablo-D3 | But hey, its great to know that the research I was performing on myself (as shoddy as it is) | 05:50 |
| Diablo-D3 | Fixes _something_ | 05:50 |
| Diablo-D3 | And I know exactly why they're doing a lot of whats on that list | 05:50 |
| Diablo-D3 | Not all of it, but a good chunk of it | 05:51 |
| Diablo-D3 | The thing is | 05:55 |
| Diablo-D3 | For awhile I've thought cognitive decline, in general | 05:55 |
| Diablo-D3 | was caused by mitochondrial disfunction then death | 05:56 |
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| Diablo-D3 | Keeping them functioning, even by force, reverses this | 05:59 |
| Diablo-D3 | Everything they've done on that list presumably contributes to it | 05:59 |
| Diablo-D3 | with no upper limit, ie, all of them together all add to the effect | 05:59 |
| lkjhfr | 13:49 < JayDugger> Optimize hygiene? What's that? | 07:50 |
| lkjhfr | 05:06 < JayDugger> optimize "oral" hygiene--what's an electric flosser? | 07:50 |
| lkjhfr | it's meant to reduce the stress on the immune system, to let it take care of more useful things | 07:51 |
| lkjhfr | i have this thing that makes me paralyzed with options when i get to interact with other people, which in result leads to either no interaction or very useless ones, it's like my mind becomes empty, and i'm slow to answer and can't find words i want to use | 07:54 |
| lkjhfr | is this some kind of disorder? | 07:54 |
| TMA | it sounds a bit like generalized social phobia | 07:56 |
| Diablo-D3 | its social anxiety basically | 07:56 |
| TMA | lkjhfr: it could be a DSM acknowledged disorder | 07:57 |
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| streety | one issue with unburdening the immune system so it is free to "take care of more useful things" is the hypothesis that this is a primary cause of the increasing incidence of allergies and auto-immune diseases | 08:20 |
| lkjhfr | isn't that when people take antibiotics, leaving the immune system with nothing to do at all? | 08:24 |
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| TMA | lkjhfr: immune system has to deal with more than killing the infection vectors | 08:27 |
| TMA | lkjhfr: ATB is somewhat like a rat poison - it kills the rats but you are left with the rat carcasses | 08:29 |
| lkjhfr | with the poison in them | 08:32 |
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| kanzure | "Reversal of hair greying following autologous adipose mesenchymal stem cell transplantations: a coincidental finding" http://www.hoajonline.com/stemcells/2054-717X/2/3 | 08:43 |
| kanzure | "Adipose derived autologous mesenchymal stem cells have been transplanted and tested for their ability to regenerate tissues for several indications. While treating various age related neurodegenerative disorders with autologous mesenchymal stem cells for their regenerative and rejuvenating properties, we accidentally observed a transition of hair colorations from mostly grey to black in all the 4 elderly patients. We have given ... | 08:44 |
| kanzure | ... 20million cells intravenous and also 20 million cells intrathecal, in multiple sessions to each patient. Though low dose the effects were very obvious and may indicate an anti aging effect. We also found that the effect was transient and changed with time through a follow up period of 20 months. This may be through positive activation and regeneration of melanocyte stem cells in the hair follicular niche. In this paper we intend to ... | 08:44 |
| kanzure | ... report this unique observation which may lead to further research and solutions to problems like premature greying of hair or indicate new anti aging solutions." | 08:44 |
| AdrianG | kanzure: have you ever seen any papers on stemcells and risks of tumor | 08:44 |
| AdrianG | tumors developing? | 08:44 |
| AdrianG | theoretically, thats the major downside of any new growth. | 08:45 |
| streety | antibiotics have other effects, but I doubt they help | 08:45 |
| streety | except in the acute phase | 08:45 |
| streety | Is there anything not in the regimen from that article that you have been doing Diablo-D3? | 08:57 |
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| Diablo-D3 | streety: yah | 14:05 |
| Diablo-D3 | "8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea. | 14:06 |
| Diablo-D3 | I dont do th melatonin or the triptophan | 14:06 |
| Diablo-D3 | not doing Citicoline | 14:08 |
| Diablo-D3 | not doing N-Acetyl-L-Cysteine (NAC) | 14:09 |
| Diablo-D3 | and not doing curcumin | 14:12 |
| Diablo-D3 | or TMG | 14:12 |
| Diablo-D3 | Im also not oxiginating myself | 14:13 |
| Diablo-D3 | and as for exercise, high impact weight lifting for roughly an hour every other day | 14:13 |
| Diablo-D3 | so I think that meets their requirements | 14:14 |
| Diablo-D3 | oh and not doing resveratrol | 14:15 |
| Diablo-D3 | .title http://news.mit.edu/2016/nanophotonic-incandescent-light-bulbs-0111 | 14:22 |
| yoleaux | A nanophotonic comeback for incandescent bulbs? | MIT News | 14:22 |
| fenn | Diablo-D3: you should probably cycle on/off the antioxidants | 14:33 |
| fenn | i don't think there's a "cure" for autism | 14:34 |
| streety | thanks Diablo-D3, is there anything you think they have missed? Optimizing iron might be one, drawing a blank on others at the moment. | 14:53 |
| Diablo-D3 | fenn: I think Im just going to drop it | 14:55 |
| Diablo-D3 | all of it | 14:55 |
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| Diablo-D3 | .title http://www.fasebj.org/content/20/9/1567.abstract | 17:40 |
| yoleaux | Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage | 17:40 |
| Diablo-D3 | .title http://www.ncbi.nlm.nih.gov/pubmed/18573711 | 17:40 |
| yoleaux | Changing expression of the genes related to human hair graying. - PubMed - NCBI | 17:40 |
| Diablo-D3 | .title http://www.eurekalert.org/pub_releases/2013-05/foas-gha050313.php | 17:40 |
| yoleaux | Gray hair and vitiligo reversed at the root | EurekAlert! Science News | 17:40 |
| -!- Quashie_ is now known as Quashie | 18:07 | |
| xentrac | yay undoing vitiligo! | 18:42 |
| xentrac | pasky: if you said things to me they've been pushed out of my scrollback buffer by lots of 01:43 < Diablo-D3> I don't believe in stuff like alcor | 18:43 |
| xentrac | 01:43 < Diablo-D3> it just seems like too much of a scam | 18:43 |
| xentrac | 01:44 < Diablo-D3> the human race is just too fucking disorganized to be useful | 18:43 |
| Diablo-D3 | heh. | 18:44 |
| xentrac | 01:52 < Diablo-D3> Humanity is just a bunch of self serving dicks, none of them interested in the greater good | 18:44 |
| xentrac | 01:57 < Diablo-D3> you want shitty? | 18:44 |
| xentrac | 01:57 < Diablo-D3> the entire silicon valley | 18:44 |
| xentrac | 01:57 < Diablo-D3> that entire fucking place should be burned to the ground | 18:44 |
| cluckj | lol | 18:44 |
| xentrac | 01:58 < Diablo-D3> ruby coders: should all be shot | 18:44 |
| Diablo-D3 | yes, we get it, Im awesome | 18:44 |
| xentrac | although I guess I've been guilty of the same kind of thing in the past. maybe including right now | 18:47 |
| cluckj | minor misanthropy isn't so bad | 18:47 |
| cluckj | as long as you remember you are part of it... | 18:51 |
| xentrac | what I'm complaining about is more the large amount of text with no information content. I mean, you could go through and read the entire rant and I doubt you'd know anything more about humanity or Alcor or Silicon Valley or Ruby programmers than you did before | 19:02 |
| cluckj | :) | 19:03 |
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| Quashie | you know, I've been thinking a lot lately about how to go about pursuing the goals I want without doing it recklessly | 19:11 |
| Quashie | my threshold for recklessness is probably too low | 19:11 |
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| kanzure | https://github.com/LightningNetwork/lnd | 20:49 |
| kanzure | https://github.com/LightningNetwork/lightning-onion | 20:49 |
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| lkjhfr | xentrac: take a look at the topic, those logs are updated in realtime | 23:10 |
| lkjhfr | bash-4.3$ wget -q -O - http://gnusha.org/logs/2016-01-16.log | tail -n 1 | 23:11 |
| lkjhfr | 23:10 < lkjhfr> xentrac: take a look at the topic, those logs are updated in realtime | 23:11 |
| xentrac | lkjhfr: of course you are right | 23:29 |
| lkjhfr | but... i'm not helpful... | 23:30 |
| xentrac | I think it was helpful | 23:31 |
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| --- Log closed Sun Jan 17 00:00:07 2016 | ||
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