2015-08-03.log

--- Log opened Mon Aug 03 00:00:29 2015
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xtalmathis black "pure" chocolate a kind of positive photoresist?03:04
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xtalmathare there any simple household photoresists?03:05
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fluffyponyhttp://www.local10.com/news/south-florida-woman-first-to-receive-bionic-eye-in-florida/3447075404:25
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xtalmathis there evidence of biological backpropagation at each synapse? is inhibitory or excitatory effect determined only by the presynaptic neuron? or can the postsynaptic neuron express different receptors to interpret a fixed neurotransmitter as either inhibitory or excitatory?04:54
xtalmathi.e. is the synaptic weight determined solely by the presynaptic neuron or both ( weight=w(pre,post) ) ? and specifically is the sign of the weight a function of solely presynaptic neuron |weight|=w(pre) ?04:56
xtalmathI guess the postsynaptic neuron has influence on the weight by expressing more or less receptors to change the magnitude of the weight. but do neurotransmitters exist for which there are multiple receptors with opposite inhibitory & excitatory postsynaptic interpretation of the same neurotransmitter exist?04:58
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xtalmathi.e. how can a neuron know in what sense to change its output synapse weights -say to accomplish learning- if there is no feedback from the postsynaptic neuron?05:03
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archelsthe classical view is that the postsynaptic neuron determines the strength of the synapse, and the presynaptic side just adjusts to match the size05:05
archelsof course this is a huge simplification, not to say just plain false05:05
xtalmathwith strength you mean magnitude?05:06
archelsyeah, amplitude of the EPSC/EPSP05:06
xtalmathI was more curious about the sign in fact05:06
xtalmathhow does the presynaptic side adjust to the postsynaptic neuron? this entails flow of information in the opposite direction of classical digital neural networks?05:07
archelsit may help to look at it the other way around. How can a neuron know how to change its input synapse weights? Well, it can just "sample" nearby axons that might be interesting.05:07
archelsdo you know about STDP?05:07
CaptHindsightxtalmath: photoresist for what application? What chemicals does it need to hold up to be be removed by?05:08
CaptHindsightor removed by05:08
xtalmatharchels: STDP is interesting05:11
xtalmathCaptHindsight: well, I would be happy if there was some "household" hardware store chemical for which any photoresist behaviour is known05:12
xtalmath(i.e. I won't be picky about poor performance, or limited processes)05:13
archelsyou can get spray can photoresist to apply coatings05:13
xtalmathyeah, you mean for PCB05:13
archelsif you spray it on a PCB, sure05:13
archelsnot sure what exotic applications you had in mind =)05:14
xtalmathare there like exhaustive lists of photoinitiators and heuristic chemical rules?05:14
CaptHindsightemulsion type photoresists for silk screen are really cheap05:14
xtalmathis that like literally artist silk screen?05:15
CaptHindsightartist, poster, t-shirt etc05:15
xtalmathhow cheap is cheap? how "ecofriendly" are they?05:15
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CaptHindsighthttp://www.advancedscreenprintsupply.com/screen_printing_emulsions.htm?gclid=CNG8q93yjMcCFQataQod3UYIdQ05:17
xtalmaththey can be spin coated? used at micron scale resolutions?05:19
CaptHindsightwhat do you want them to adhere to?05:20
CaptHindsightxtalmath: thats why I asked the application and how they would be removed rather than play 20 questions05:21
xtalmathI am sorry05:22
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xtalmathwhat was my last msg?05:59
archelslog url in topic06:02
xtalmatharchels: I don't understand how a neuron can change its input weight? and suppose it is according to some rule trying to change the sign of the weight (i.e. from "0.01" to "-0.02")? it should then somehow demand the previous neuron to use a different neurotransmitter? i.e. what exactly is inhibitory/excitatory? strictly the transmitter molecule? or also the receptor?06:06
xtalmathif also the receptor, then it is very misleading to have inhibitory/excitatory neurotransmitter terminology. I believe that fundamentally there must be backpropagation at the neuronal level, I can't believe all learning to pass through some global "good/bad" brain variable.06:07
xtalmathalso, how does the single neuron adjust a specific input weight to react more or less inhibitory/excitatory, without equally adjusting the other input weights?06:07
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archelsxtalmath: look up Dale's law06:09
xtalmathfurthermore, only adjusting the input weights cannot cause backpropagation, since that would require postsynaptic neurons somehow influencing the current neuron's firing. Information must cross the synapse in both ways for backpropagation to work. Unless backpropagation for learning requires cyclic connections.06:09
archelsbackprop is just a theoretical construct. It (very very likely) does not happen in biology.06:09
kanzureweights can be changed by adding and removing ampa receptors06:10
kanzureand the amount of expression is some obnoxious methylation thing or transcription cofactor thing06:10
kanzurealso regulation of expression of nmda receptors plays an important role in modulation of plasticity and synapse weighting06:11
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xtalmatharchels: well I can still imagine "backpropagation" mechanism to work at a very low level, for those circuits that contain cyclic feedback connections. but that does not explain learned patterns in feedbackless parts of the brain (if they even exist? perhaps the neurons most closely connected to input sensors, like close the retina).06:15
archelsthe retina is an exceedingly intricate neural tangle06:16
archelsyou're right, but only for very simple peripheral sensors such as mechano-, pain receptors06:17
xtalmathkanzure: to be honest I don't see how transcription (co)factors and gene regulation can target a specific input weight among the many of this same neuron cell?06:17
kanzureit's not a specific input weight06:17
kanzureit's just more/less of the same06:17
xtalmathkanzure: so according to you there is backpropagation at neuronal level?06:19
xtalmathI don't even understand how this is still a question of debate with all these fluorescence microscopy and neuron chips...06:20
kanzurehttp://diyhpl.us/~bryan/papers2/neuro/Review%20-%202007%20-%20AMPA%20receptor%20trafficking.pdf06:21
xtalmaththx06:22
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xtalmathare there publicly available large datasets of neuron fires and synaptic protein levels for a bunch of connected neurons (say on chip or in culture)?06:40
xtalmath"In particular, neurons haveevolved specific pathways to transport mRNAout  into  dendrites,  where  subsequent  localtranslation can occur" ! thx again kanzure06:48
xtalmathso it is probably translation modulation instead of transcription modulation06:49
xtalmathand somehow local (because of long dendrite distance, I assume the concentrations at different synapses can be very different, while having low concentration gradients along the long dendrites...)06:51
xtalmaththey are almost seperate cells06:52
xtalmathone could speculate that different synaptic weights of the same neuron are correlated by how close they are as leaves on dendrite branches...06:55
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kanzurehttps://soundcloud.com/progressivehouseworldwide/sets/phw-elements-radio-digitally08:19
JayDuggerAnyone know 1) what relationship Rob Rinehart has with Soylent, and 2) what's this about "Soylent 2.0"?08:26
JayDuggerSee here: http://robrhinehart.com/?p=133108:28
kanzurerecipe is at http://robrhinehart.com/?p=42408:28
kanzuresee http://gnusha.org/logs/2013-02-20.log08:29
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JayDuggerThank you.08:33
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ParahSailin_so he claims that the algae oil is more efficient than plant oil09:01
ParahSailin_you'd picture the algae being harvested from a solar pond of some sort right?09:01
ParahSailin_nope "Solazyme grows microalgae in the dark, inside huge stainless-steel containers. The company's researchers feed algae sugar, which the organisms then convert into various types of oil. The oil can be extracted and further processed to make a range of fuels, including diesel and jet fuel, as well as other products09:01
kanzureyes, solar doesn't work with dense algae ponds without lots and lots of mixing09:02
ParahSailin_corn09:02
nmz787_iomg like no one has figured out mixing09:02
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ParahSailin_soylent guy is pretty delusional09:03
chris_99how bad does soylent taste out of interest09:03
ParahSailin_1.3 tastes like oatmeal09:04
ParahSailin_he should have stuck to the high oleic sunflower09:04
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nmz787_i1juri_: the SEM I've got is a JSM-T20011:24
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juri_nmz787_i1: i've got a cambridge stereoscan 200 here.11:34
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FourFirenmz787, If you grow algae in the dark you don't need to tye up so much land surface area12:00
FourFireand there are issues with grime buildup on the inside of the glass tubes12:01
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HoushalterFourFire, well the sugar has to come from somewhere.12:18
FourFireyes, but cane fields are a mature technology, and cheap12:26
FourFirebut building out glass tubes and maintaining them is probably way more epxnsive if you have to do it spread out over many square meters, instead of in an efficent, cubical building12:27
Houshalteralgae is more efficient at photosynthesis12:27
Houshalterby like a lot12:27
delinquentmewhy no go up?12:28
Houshalterin 20 years most sugar will be produced by algae12:28
delinquentmealgae in vertical could be mush cheaper no?12:28
FourFiredelinquentme, shadows12:28
delinquentmeHoushalter, in 20 years well be on silicon :12:28
delinquentmeFourFire, penetration12:29
FourFirealso, water pressure?12:29
Houshalteri doubt that12:29
delinquentmearrange it that darkest growth is at bottom12:31
FourFiredelinquentme, I doubt it (silicon)12:33
delinquentme::D12:33
FourFiremaybe in 40, a large minority will be, but at significant personal disadvantage12:34
FourFireok, clear with me, how tall do you picture these vertical tubes?12:34
FourFireHoushalter, I'm sure at larger scale, the incresed energy efficiency will make the initial capital investment of vast fields of glass worthwhile, but not before12:35
FourFirea large company with loads of capital and the will to spend it makes it happen12:36
ParahSailin_open ponds seem more worthwhile12:37
delinquentmeParahSailin_, stop being so contrarian12:38
ParahSailin_glass is pretty expensive12:38
ParahSailin_can you imagine glass on a cash crop scale?12:39
delinquentmeFourFire, also if you aerate from below, you can adjust aeration rate to get  a nice density gradient upwards12:39
FourFireParahSailin_, that's my point12:40
FourFirebut open ponds waste water12:40
ParahSailin_yeah thats problem12:40
FourFirewe donæt have that much water unless we've solved energy and can just desalinate12:41
ParahSailin_theres algae that grow in saline12:41
FourFireyou don't want to salt that much land12:41
ParahSailin_theres lots of australia thats just wasteland12:42
ParahSailin_the chinese at one point had a plan to turn some of the desert into an inland sea12:43
ParahSailin_with massive amounts of pumping12:43
delinquentmedo you meant that semiconductor wastewater oasis?12:44
delinquentmetheres no salt! just a few heavy metals !12:44
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HoushalterFourFire, maybe, sugar is quite expensive.12:48
HoushalterFourFire, not everyhwere in the world has a water shortage12:49
Houshalteri live in a former swamp and we have more water than we know what to do with12:49
FourFireno, but if we begin to actually use our resources efficiently in order to develop the amount of infrastructure we actually need, we will quickly run short of anything we don't produce12:50
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delinquentmeFourFire, that can be said for the sun.12:51
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FourFire(non/slowly renewable ground and surface freshwater being one of those resources)12:52
Houshalterwater is not a finite or even particularly scarce resource. If you are using it for algae, it doesn't even need to be clean.12:52
FourFiresure, but how much oil are we using?12:52
FourFirehow much oil will we need to power the world in 10, 20 years12:52
FourFirewe're going tp have to cover the majority of the petroleum supply with bio alternatives, because of the peak12:53
drethelinpeak oil is not a thing12:53
drethelinpeople talk about the available supply running out12:54
FourFireHoushalter, what's the billion words dataset?12:54
drethelinbut that's because people only spend the minimum amount possible ot maintain an available supply12:54
HoushalterFourFire, what how did you find out about that?12:54
drethelintalking about only having enough oil to last us a few years is like talking about grocery store food only lasting us a few days12:54
FourFiredrethelin, we aren't going to exhaust available oil, we'll just use up all the priftable oil12:54
drethelinthat's a nonsensical statement12:54
drethelin"profitable at what price"12:55
HoushalterFourFire, it's not the amount of oil that needs produced ,it's whether it's even economical at all12:55
drethelinnot "profitable oil"12:55
drethelinconsider this: it costs money to find oil12:55
delinquentmekanzure, surely someones algae'd in here before12:55
drethelinthis money needs to be spent to find it12:55
drethelinif you have a large stockpile12:55
drethelinwhy would you spend money finding oil12:55
Houshalterwe will worry about running out of fresh water to grow algae when we are already producing thousands of gallons a minute in a swamp somewhere12:55
drethelinbefore you have to?12:55
kanzuredelinquentme: i worked on an algae biofuel project and an alge insulin project, what do you want12:55
FourFiredrethelin, about opportunity cost12:55
Houshalternothing wrong with using sea water either12:56
delinquentmeI want dougnuts12:56
FourFireif you need to provide X energy per time in order to have Y productivity otherwise it will cost you Z strategic position12:56
delinquentmebut these guys are algaeing or brainstorming on it12:56
FourFirethen you pay for X12:56
HoushalterFourFire,  https://www.kaggle.com/c/billion-word-imputation12:57
FourFireof course, I'd prefer that we all just put solar panels on our roofs and found a better method for electrical energy storage and upgraded out logistics netowrk to electric tech12:57
FourFirebut that's not going to happen in time12:57
drethelinin time for what12:57
drethelinyou're getting your predictions from status-whoring fearmongers12:58
drethelinthe other thing is12:58
drethelinthere is no discontinuity12:58
drethelinwe won't "suddenly" run out of oil12:58
FourFiredrethelin, in time to provide for rising demand as supply shortfalls12:58
drethelinthere's not a due date12:58
drethelinthere will be no supply shortfalls12:59
FourFireof course not, we're gradually lowering production12:59
drethelin'I hope next year's crops come in in time to make up the supply shortfalls from last year!"12:59
drethelinit's an incoherent position13:00
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FourFireok, the catastrophe I am implying is a dramatic lowering in median wealth, because the cost of using, energy, on a personal basis, and indirectly resources which require energy to be produced, will be relatively higher over time rather than lower, as the trends have been these past... what 300+ years?13:00
drethelinyes13:00
drethelinand Im saying that will never happen13:00
drethelinit will not be dramatic13:01
drethelintechnological improvements are dramatic changes13:01
FourFireok, what reason leads you to believe it?13:01
drethelinbecause markets are a thing, and aggregation is a thing13:01
drethelinthere is not some single big pool of oil that will suddenly run out13:02
Houshalterdrethelin, yes oil prices have never increased rapidly before and it's totally impossible they could ever do that to a greater degree13:02
FourFireOk, I admit that my mental state is unstable today13:02
FourFiretoday has been a pessimistic day from my perspective, due to IRL events13:02
drethelinHousehalter: oil prices have both increased and decreased rapidly13:02
FourFireHoushalter, you will have noticed this from our earlier discussion13:02
drethelinbut not from some cosmic or environmental reason causing us to run out of oil13:02
FourFireI didn't say anything about cosmic13:03
FourFireThe model behind the concept of peak oil is based off a well regarded geologist's research13:04
Houshalterthey are pumping it out of the ground much faster than it's economically rational to do13:04
drethelinwhat does that mean13:04
FourFireI mean, sure, I'm hopeful that this time Fusion isn't just 20 more years away13:04
drethelinwhy would they do that?13:04
drethelinFourfire: so is every model that has failed to come true13:05
FourFirethat the price of solar panel production and installation will fall below the price of purchasing firing oil, or gas13:05
drethelinthere are THOUSANDS of well regarded scientists in almost every field13:05
drethelinsome of them will ALWAYS predict disasster13:05
Houshalterwho's they? You have a bunch of oil in the ground and you need to sell it. In the long run it would make way more sense to keep it in the ground and wait till prices rise, but who is going to take that bet? With who's money?13:05
drethelinpeople thought there was going to be a giant population crash or an ice age or mass starvation13:05
Houshalterdrethelin, oh yes someone in the past made a bad prediction therefore all predictions are wrong and bad things can never happen13:06
FourFireyeah we stalled the ice age bac in the bronze age, due to deforestation13:06
FourFirepopulation crash, we invented fertilizers and other agriculture stuff13:06
drethelinHoushalter: predicting the end of the world makes you well known and noticed. It should be no surprise that predictions of the end of the world are more common than world ending events13:06
FourFire we learned how to make a world that sort of worked, where <5% of the population produced the food for everyone13:06
FourFireand we did it all by burning petroleum13:07
FourFiredrethelin, I'm not predicting the end of the world, just a slowing down of technological development, which is personally fatal13:07
FourFirehey I'm all for looking forward to the best futre, where technology accelerates just fst enogyh, where we platau at above average human artifical general intelligences and fix all the coordination problems, then launch into space, and then AI takes off due to massive amounts of computational resources made avilible by permitting recycling of the earth's constituent atoms (once we've recorded it, of course)13:10
delinquentmeooo theres an interesting storage problem.13:11
delinquentmeif we wanted to 'store' the arrangement of atoms on the earth. How large would that storage medium need to be13:11
HoushalterFourFire, that is a rather specific prediction of future events and depends on a lot of things going just right13:11
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FourFireyeah, a lot could go wrong13:12
FourFirethere could be antagonistic social warfare if tech progresses too quickly, too visibly13:12
HoushalterI just count on one thing going right: FAI. Everything else is a distraction13:12
FourFirewe could completely lose control to half formed artificial intelligences13:12
drethelinthe point is not that something ccan't go disastrously wrong13:13
drethelinthe point is that any given disaster that someone is pushing is probably more self-serving13:13
drethelinthan it is informative13:13
drethelinand that for a LOT of disasters we have good evidecne that they are not in fact imminent13:13
FourFirewhich is the most likely thing to go wrong, besides things we already know for sure, climate change, etc.13:13
drethelinclimate change is a paper tiger13:13
FourFireit's no danger to pretty much anyone right now, but if we donæt do anything about it, then a lot of people are going to be dying/moving in the 50s, onwards13:14
eudoxiathe way i see it, there's two competing trends: ephemeralization (leads to MNT) and resource exhaustion (leads to war etc.), and i don't really know which trend will overtake the other13:14
Houshalter" list of major governments in 1900 would probably put the Ottoman Empire or Austria-Hungary well ahead of the relatively young United States.  Citing the good track record of the US alone, and not all governments of equal apparent stability at the start of the same time period, is purest survivorship bias."13:14
Houshalterhttp://lesswrong.com/lw/hy/riskfree_bonds_arent/13:14
eudoxiaalthough to be fair the world3 business-as-usual scenario has more or less been on track with reality and leads to mass die-offs13:14
drethelinI'm with taleb and scott adams13:15
drethelinslow moving predicted risks are not what you should be worreid abou13:15
kanzure"lose control" you never had control13:18
eudoxiaheh13:18
FourFireeudoxia, the problem with ephemeralization is that a lot of the gains are lost to https://en.wikipedia.org/wiki/Jevons_paradox13:19
FourFiresuddenly people can do really expensive stuff, for the same cost as doing earlier stuff13:20
FourFireand sometimes that expensive stuff is wasteful or even harmful to other resources13:20
FourFiredrethelin, is AI "slow moving"?13:22
FourFiremeh I'm giving it up for the day, not in a contructive mood13:23
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drethelinAI is not slow moving13:23
drethelinneither is a bio engineered pandemic or an asteroid impact13:23
juri_lets get working on AI, improved biology, and leaving the planet then.13:26
drethelin"improved biology'13:26
drethelinthe problem there is working on improved biology is exactly the sort of thing that would let someone make SmallAidsPox13:27
juri_AI -> drone warfare && rockets -> ICBMs. we've survived those.13:28
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archelshttp://www.nrel.gov/news/features/feature_detail.cfm/feature_id=1953213:32
archels"C02"13:32
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kanzurec0rw|timetravel: greetings13:35
c0rw|timetravelhello kanzure13:35
c0rw|timetravelhello transhumanists also13:35
eudoxiahello13:36
kanzureare you defecting13:38
c0rw|timetravelwho, me?13:40
c0rw|timetraveldefecting against what ?13:41
kanzurelesswrong13:45
c0rw|timetravel... they don't like h+ ?13:45
kanzureit's an existential risk to them13:46
c0rw|timetravelfrom here i don't see how (yet)13:48
drethelindo you mean they view it as an existential risk13:49
kanzureyes13:49
drethelinor that the H+ cocmmunity is an existential risk to the lesswrong community13:49
kanzureno13:49
kanzurebecause both communities are equally ineffective13:50
drethelinsure but communities that share mindspace are probably the biggest threats to each other's xontinued existence13:50
c0rw|timetravelno13:50
c0rw|timetravelsubculture archipelago says they're not13:50
c0rw|timetravelnothing prevents anyone from being in both, and more or less involved with either13:52
drethelinit's not about prevention13:53
kanzureer, right, i am just teasing you13:53
c0rw|timetravelincompatible goals?13:53
kanzureyes kinda13:54
c0rw|timetraveli don't see how, but then i just arrived here13:55
kanzurearen't you c0rwin?13:56
c0rw|timetravelyes13:56
kanzureexcuse me, i mean c0rw1n13:56
c0rw|timetraveli use c0rw|timetravel for when i might respond in channels to things said hours ago13:57
kanzuretime travel is pretty dangerous13:57
c0rw|timetravelLOL13:58
drethelinhttps://www.youtube.com/watch?v=hG5I-54Yu4o'13:58
drethelinhttps://www.youtube.com/watch?v=hG5I-54Yu4o13:59
kanzure.title13:59
yoleauxI *WILL* MESS WITH TIME - Rick and Morty Season 2 Episode 1 - YouTube13:59
kanzurei was thinking more like https://www.youtube.com/watch?v=KJRh-37H4fA13:59
kanzureor https://www.youtube.com/watch?v=k-e640rn8S414:02
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c0rw1n... what is it that h+ wants to do that lesswrong would find an x-risk ?14:18
kanzureintelligence augmentation14:18
kanzurenootropics14:18
c0rw1n*blink* *blink* how do they NOT want that ?14:18
kanzurerecursive self-improvement14:18
kanzurewhat? they think that's the fucken end of the world.14:19
drethelinkanzure as always you are being a jackass14:19
kanzurego on14:19
drethelinin general Lesswrong approves of nootropics and intelligence augmentation14:19
drethelinIN HUMANS14:19
drethelinbecause the timescales for recursive self improvement are long enough that if something crazy starts happening you can react14:20
kanzurenobody at lesswrong strongly believes that recursive self-improvement is particularly safe in humans but not ai14:20
drethelinreally?14:20
drethelinI would best most people would if you asked them14:20
drethelinbet14:20
kanzurebecause humans are friendly....?14:20
drethelinbecause humans are SLWO14:20
drethelinSLOW14:20
kanzureso something like "humans are so slow that no amount of recursive self-improvement would fix that slowness"?14:21
drethelinhumans are not capable of recursive self improvement to the same extent as digital entities14:21
c0rw1n.. yet ...14:21
drethelin"yet"14:21
drethelinthere is no yet about it14:21
drethelinat the point where humans can recursively self improve as fast as a totally digital intelligence they will no longer be humans14:21
c0rw1n( this is *begging* to go into "is an Em an human" isn't it )14:21
kanzurethat's just semantics14:21
drethelinlike talking about a cheetah that can outrun a rocket14:21
c0rw1nyeah14:21
kanzurenobody cares if they are human14:21
kanzureand why can't my rocket cheetah count?14:22
drethelinbecause it's the rocket that's fast14:22
kanzureethics board said no, that's why i left to start my super zoo14:22
drethelinif you strap a human to a recurisvely improving computer14:22
drethelinit's the computer you should be scare of14:22
kanzurestrapped a rocket to a cheetah but then this happened http://vignette2.wikia.nocookie.net/familyguy/images/1/19/Chester_Cheetah.jpg/revision/latest?cb=2009090719031714:22
Houshalteryou can tie a rocket to the back of a cheetah, but it kills the cheetah14:22
drethelinconsider how long it takes to run ONE experiment on human improvement14:22
c0rw1nin the space of possible goals to have, humans generally cluster around a pretty tiny place14:22
drethelinhumans can't install extra ram14:23
c0rw1nmachines, well, mumble murgle clippy14:23
drethelinthey can't control multiple bodies simultaneously14:23
drethelinor network14:23
c0rw1nyet14:23
kanzuredrethelin: i think that you seem to have a broken definition of improvement14:23
drethelinkanzure: ?14:23
kanzuresmall improvements can lead to other improvements14:24
drethelinyes14:24
drethelinand?14:24
kanzureperhaps your argument is "humans would take so long tha ti expect that ai stuff will happen before anything interesting happens"?14:24
kanzure*that i expect14:24
drethelinyeah pretty much14:24
drethelinhuman generations are slow14:25
kanzureyou don't need human generations14:25
drethelinyou don't ALWAYS need them14:25
kanzuredid i ever mention my nootropics plans14:25
drethelinI assume they're absurd14:25
drethelinbut right now our most promising avenue for understand intelligence and intelligent enhancement is genetic14:25
drethelinI think14:25
drethelinin which field you need generations to test innovations14:26
kanzuremicrobial nootropics14:26
drethelineven if we learned to clone von neumann14:26
drethelinhe'd still have to grow up14:26
c0rw1nnootropics can  only marginally augment flesh capabilities, even if it's like one or two OOMs, digital would go so so much further14:26
kanzureselection for which microbes migrate to certain brain regions14:26
kanzurec0rw1n: yes but we don't have human brain emulations yet, so.....14:26
c0rw1ninorite ;_;14:26
kanzurei'm also not convinced about upper limits of flesh capabilities14:27
kanzurethere's a lot of stupid brain mass14:27
drethelinso my belief is basically, there are two main "steps" to recursive intelligence improvement14:27
drethelinhardware and software14:27
drethelincode optimization and hardware improvements14:27
drethelinin both of these humans are harder to work in than digital entities14:27
kanzureso far digital entities haven't been made yet14:28
kanzurebe practical14:28
drethelinok fair point14:28
drethelinbut code optimization is still a thing we sometimes do14:28
kanzuresee http://diyhpl.us/wiki/projects/human-like-cognitive-abilities/14:28
drethelin(when we're not relying on having more processing power than we know what to do with)14:28
drethelinbut a human's ability to access and modify his code is negligible14:28
drethelincompared to a theoretical AI's14:28
kanzureyes compared to some imaginary bullshit, it can be whatever14:29
kanzurethis doesn't help me14:29
drethelinI'm not trying to help you?14:29
kanzureno, i mean comparison to AIs doesn't help me14:29
drethelinagain14:29
drethelinI'm not ttying to help you14:29
drethelinI'm trying to explain why lesswrong mostly doesn't give a shit about recursive human self improvement14:29
kanzureyou were trying to argue about why self-modifying humans could never go fast enough14:29
kanzurewhy wouldn't a self-modifying human be faster at making accurate human brain emulations than a non-self-modifying human?14:30
kanzurehmph14:30
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drethelin??14:30
drethelinbecause a human can't self-modify fast14:30
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c0rw1nwhy emulate a human brainin a human brain ...14:30
kanzurec0rw1n: because emulating a mouse brain is less useful14:30
drethelinif a human comes up with an improvement to the humman equivalent of RAM architecture14:30
kanzuredrethelin: i don't think that's true; the design-test-build cycle can be significantly shortened.14:30
drethelinhe still can't exactly slot that into his own brain saffely14:30
drethelinthe way a computer can14:31
kanzurethat's true, you need sandboxing, but so what14:31
c0rw1nyeah, would need backups14:31
drethelinso that slows things down A LOT!14:31
kanzurecompared to something that doesn't exist yet :-)14:31
drethelinneither does your theoretical bullshit enhanced human14:31
drethelinso cut the sass14:31
kanzurenootropics exist (although they are all weak)14:31
drethelinweak enough that we only have anecdotes for net beneficial effects14:32
kanzureso you're not too hot on the microbial nootropics plan, eh?14:32
drethelinno I like it14:32
drethelinI'm in favor of human enhancement14:32
kanzurehm.14:32
drethelinI'm just not worired about it going recursive and creating someone smart enough to take over the world14:32
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kanzurei think a person could already take over the world, without the assistance of a nootropic14:33
c0rw1n... 'finil and 'cetam seem to work preeetty well doe't they ( but ok, no order-of-magnitude improvement there though )14:33
c0rw1ni t'm really not sure14:33
c0rw1n*i'm14:33
drethelindepends on your definition of take over14:33
kanzurec0rw1n: my definition of a minimally-viable nootropic is a nootropic that endows you with the ability to make a better nootropic14:33
kanzureit's an escape-velocity nootropic thing14:33
drethelinpeople clearly can do stuff like be Stalin or Mao14:33
drethelinhmm14:33
c0rw1nheh, then feed finil and cetam to a bunch of pharma researchers?14:34
drethelinwho are the biggest names who use nootropics?14:34
kanzurehell yeah14:34
kanzuredrethelin: erdos14:34
drethelinheh14:34
drethelinmore like erdosseral14:34
drethelinadderalldos14:34
kanzureoh come on be nice14:34
drethelinhmm14:34
kanzuresounds like a children's story14:34
drethelinanyway I said use not used14:34
drethelindoes musk or tao use modafinil?14:35
c0rw1nwho knows14:35
kanzuremusk just never sleeps instead14:35
drethelinimagine if people are right about how important sleep is14:35
drethelinand he would actually justs be wway smarter14:35
drethelinif he slept 8 hours14:35
kanzurei don't know if it's smartness that he needs more of14:36
drethelinfair14:36
kanzurei guess it would always be nice eh14:36
drethelinwho's the elon musk of biotech14:36
kanzurecraig venter :-(14:36
delinquentmeme14:38
kanzureyou don't have the cheeks for it14:38
delinquentmesomeone touch muh butt?14:39
delinquentmeroflmao14:39
delinquentmesorry idk why my OKC persona crossed w the transhumanist14:39
kanzurenah that's how i setup mine14:39
drethelinhmm14:40
drethelinI wonder if I should be more openly transhumanist on okcupid14:40
kanzuremy profile is... definitely transhumanist.14:40
kanzurehttp://web.archive.org/web/20150625162512/http://www.okcupid.com/profile/kanzure14:40
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delinquentmeI want to buy a cell line . but not pay the commercial cost14:50
kanzureerdos seems like an alright role model14:50
delinquentmehow do I do this?14:50
delinquentmeor at least ... I'd like to defer the cost14:50
drethelinyou could go to a university or somethin14:50
drethelinask a grad student to breed you some cells14:50
kanzurehow can you not afford a cell line, i thought you had a $200k budget14:50
c0rw1nhow are the commercial ones manufactured ?14:50
drethelinpay for the growth media and so on14:50
justanotheruserkanzure: why do you like on your profile?15:00
justanotheruser*lie15:01
drethelingives romantic partners the fun of uncovering the truth15:01
c0rw1nlulz15:01
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justanotheruserDrugs Never15:01
drethelinprobably because the standard definition of Drugs15:02
drethelinis like "marijuana and cocaine"15:02
drethelinand not "noopept and theanine"15:02
kanzurebecause "i have 200 empty adderall bottles" wasn't any of the answer options15:03
chris_99haha15:03
justanotheruserdo you put them on a shelf like a frat boy puts liquer bottles in a shelf?15:04
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juri_with all that's wrovg with me, i now store smaller parts of laptops (screws and such) in perscription bottles.15:05
kanzureno clue15:05
c0rw1nthat's a good idea15:05
c0rw1nprevents loss of screws and such15:05
kanzureyou can also just use sticky tape15:07
drethelinprescription bottles are actually a really good little container15:07
drethelintransparent and they won't all open accidentally if you drop em15:07
c0rw1nyeah, seems like a perfectly good storage method15:09
c0rw1nnothing wrong with it, nor with you for using it15:10
delinquentmehttp://www.dorkly.com/post/75600/watch-ronda-rousey-gush-about-her-cartoon-crush-vegeta # off topic ish15:10
kanzurevegeta is completely on topic15:10
c0rw1nhow so ?15:11
justanotheruservegeta is transhuman15:12
kanzurehttps://www.youtube.com/watch?v=lgaYv37stMk15:13
kanzurehe's hilarious15:13
drethelinvegeta isn't a huma115:13
drethelinhuman15:13
kanzureaww it didn't show the gorilla part15:13
justanotheruserdrethelin: Yeah he's not human, he's transhuman, that's what I'm saiyan15:15
c0rw1n>.<15:15
drethelinughghghghghghghghg15:15
kanzureplus his scouter15:17
drethelingoogle glass power level over 1500$15:17
c0rw1nBWAHAHA15:17
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nmz787_i$48k for post-halcyon-tech portable SEM (small enough to fit in large backpack)16:02
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eudoxiaoh my god16:07
eudoxiai was reading old logs16:07
eudoxiahttp://gnusha.org/logs/hplusroadmap-logs/2012-07-19.log16:07
eudoxiakanzure: was the guy who contacted you about pyphantomjs this guy https://github.com/san-mate16:07
c0rw1nyeah, what timestamp pls ?16:07
c0rw1noh, not for me16:08
c0rw1n'k16:08
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kanzurenot sure16:13
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eudoxiawell, i did not know him in 201216:15
eudoxiabut if he was that person then he was employed where i work16:15
eudoxiawhat a small world huh16:15
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nmz787_iso ibidi makes a disposable fludic that almost would work for the TdT synthesis...16:33
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nmz787_ihttp://ibidi.com/xtproducts/en/ibidi-Labware/Flow-Chambers/m-Slide-Membrane-ibiPore-Flow16:34
nmz787_isimpore says they could help me build a similar device using their nanoporous product instead of the microporous one16:34
nmz787_i(i've talked to simpore about this before, years ago, since they were in Rochester)16:36
kanzureacetaminophen-producing bacteria https://news.ycombinator.com/item?id=1000002616:49
CaptHindsightnmz787: do you know the range of pore sizes of the nanopore versions?16:50
CaptHindsightis there more than just the 0.5um?16:51
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nmz787_iweel the 0.5 is a microporous16:54
nmz787_ithey can tune the size from like 5nm up to 100s I think16:54
nmz787_iwith variation in size increasing with increased target pore size16:54
nmz787_iso if we wanted a 20nm pore on avg... we'd get a spread from probably 10nm to 30nm in range16:55
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nmz787_iso well within oligo diameter, and well away from enzyme size16:55
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fennso steve said something worrying about my complaining about the mouse brain ATUM/EM scan thing in nature the other day18:00
fenni said "it's not very useful because there isn't even an entire cell in the scanned volume" and he was like "good. that means more time to develop FAI theory in the small window between developing enough credibility to raise funding and the emergence of neuromorphic AI'18:01
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fennthus putting ${people who want to understand the brain} into conflict with ${people who want to save the world from AI}18:02
c0rw1n"save the world FROM ai" group is already a roadkill of history, like feudalists and communists.18:03
c0rw1nMight be getting somewhere on "save the world USING AI" , yes.18:03
fenni don't get what these math people think they are doing, when they have no direct experience with how an AI works18:05
fenn(because there aren't any in existence afaik)18:06
fennthere is a long roadkill of history of people pretending they know what AI will be like18:06
c0rw1nlooks like a standard fallacy there fenn18:06
c0rw1nwe already have a lot of AI tech18:06
c0rw1nnot AGI yet, sure18:06
fennit looks just as bad as the boundless optimism of mccarthy in the 70s with regards to symbolic ai18:07
fenn"we don't understand how motivation works but let's make lots of predictions about it anyway"18:08
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c0rw1ndon't patternmatch to that. It'll be neuromorphic AI. Maybe not with the sort of NNs we have now, maybe we'll need finer values than just one input and one output numbers per neuron per tick, but it'll happen and it'll happen there.18:10
fennuh 1960s i mean18:10
fennpre-1969-singularity :P18:11
fennMoravec explains, "Their initial promises to DARPA had been much too optimistic. Of course, what they delivered stopped considerably short of that. But they felt they couldn't in their next proposal promise less than in the first one, so they promised more."18:12
c0rw1nlol @ the dance of incentives18:12
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fenni'm pretty impressed with the capabilities of RNN and deep belief networks, but i don't see anyone combining them into agents that try to actually do anything at all, they are just used for prediction and classification18:14
c0rw1nnah, there is much scarier than that18:14
c0rw1ntiling NNs in cortical-like structures18:15
fennwhat's the difference between that and a deep belief network18:15
c0rw1ncould well make a full brain with those, idk that deep belief networks are that neuropmorphic18:16
c0rw1nbut then idk deep belief nets so idk18:17
fenni think they are pretty similar in layout, it's just a matter of parameters18:17
c0rw1noh. ok then18:18
* c0rw1n goes google for DBNs18:18
fennthere is a ton of other biological squishy stuff that probably matters too, but apparently it's not as important as the basic architecture because deep belief networks actually work18:18
fennit's just a multilayer neural network18:18
c0rw1nnah, i mean .. ok you know how the visual cortex is a bunched-up plane of hypercolumns of neurons18:19
c0rw1nand RNNs doing visual works like classification are not18:20
fennlike i said, it's just parameters18:20
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fennyou can set your minicolumn size to equal the human brain or not18:20
c0rw1ni think the structure itself is what's important (and i might well be completely, spectacularly wrong)18:21
fennsure it's important but that doesn't mean only one parameterization will be able to do things in the world18:22
c0rw1noh, agreed18:22
fennsupposedly autistic people have smaller minicolumns in larger numbers, and some of them are extremely talented18:22
c0rw1n's just, we have a model that we know already works (natural brains), so let's begin by replicating that and then see how to optimize it18:23
c0rw1nalso i want muh upload ^_^18:23
fennsure i agree that's the best approach because the machine will at least be understandable to humans18:24
* fenn looks at http://minicolumn.org/publications/autism-pamphlet.html18:24
nmz787_i.tell fourfire why not just use a salt-water algae?18:26
yoleauxnmz787_i: I'll pass your message to fourfire.18:26
fennthe ethylene thing is cute because it sidesteps the "how do we collect all these tiny things that clog filters" problem18:26
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fennremoving water from the algae culture was the hardest part of the process18:27
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fennnmz787_i: cyanobacteria already grow in salt water18:27
fennfourfire was just doom-mongering18:27
nmz787_ifenn: the obvious answer is to engineer a lipid membrane-pump (system)18:28
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nmz787_iso there was an xray sensor guy at the conference (i spent all afternoon in the vendor area, wow, I wish the local mall had a tech wing like that)18:30
nmz787_iand I saw the opamp next to the Silicon pin-diode;18:30
nmz787_iand he told me they use peltier to cool the sensor and FET, but nothing else18:30
nmz787_iwhich is pretty cool18:30
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nmz787_iand then SPI chem suppliers had a self-contained battery-powered microfluidic pump with a SiNi window over the microchannel (in PDMS) and after bonding the window to the microchannel, they put a 3 micron hole in the SiNi window... then put the whole thing in an SEM/TEM18:32
nmz787_iI guess SEM18:32
fennyou can do x-ray spectroscopy with that sensor?18:32
nmz787_iand he said the surface tension was enough to keep the water/liquid from escaping, and that evaporation wasn't enough to foul the e-beam or imaging/xray analysis18:32
nmz787_ifenn: oh yeah, PIN diodes have a thickness corresponding with the energy of xrays18:33
nmz787_iI didn't think of a peltier to cool it though18:33
nmz787_ithe older alternatives were SiLi which have been superseded by SDD (silicon drift detector)18:34
nmz787_ibut PIN are common for handheld xrf spectrometers18:34
nmz787_i(he said)18:34
nmz787_ijust slower18:34
nmz787_iand don't /need/ cooling with LN218:34
nmz787_i(as SiLi and SDD do)18:34
nmz787_ikanzure: wanna buy me a $48k mochii SEM?18:35
nmz787_i(USA made)... or a 70k / 120k (comes with edx) larger korean one?18:36
nmz787_i2 week lead time on either18:36
nmz787_ihttp://www.coxem.com/ds1_1.html18:36
nmz787_ithe mochii is small enough to fit in a backpack, while the coxem is not18:38
nmz787_ibut it could fit into a compact car18:38
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nmz787_i.title http://www.google.com/patents/US859852718:57
yoleauxPatent US8598527 - Scanning transmission electron microscopy - Google Patents18:57
nmz787_ithey immediately start to talk about DNA sequencing18:57
nmz787_i"Larger acceptance angle may improve resolution. Because of this relationship between the acceptance angle and resolution of STEM 10, the acceptance angle can be selected based on the desired resolution. For example, if 1 Ångström resolution at 100 kilovolts is desired, it may be desirable to have at least about 30 milliradians acceptance half-angle, or even at least about 40 milliradians acceptance half-angle. In one example, single-atom19:03
nmz787_iresolution—namely resolution at least as good as about 0.3 nanometers and in some instances at least as good as about 0.15 nanometers—may be desirable for a DNA-sequencing application. However, with an angular range that is unnecessarily high, current may be wasted undesirably. Once a suitable accelerating voltage is chosen, the desired resolution may determine the acceptance angle of objective lens100."19:03
nmz787_iOwner name: MOCHII, INC. (D/B/A VOXA), WASHINGTON19:04
nmz787_ihrmm, i can't find any further info... I almost want to go back tomorrow19:05
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nmz787_i.wik precession electrondiffraction19:12
yoleauxnmz787_i: Sorry, that command (.wik) crashed.19:12
nmz787_i.wik precession electron diffraction19:12
yoleaux"Precession Electron Diffraction (PED) is a specialized method to collect electron diffraction patterns in a transmission electron microscope (TEM). By rotating (precessing) a tilted incident electron beam around the central axis of the microscope, a PED pattern is formed by integration over a collection of diffraction conditions." — https://en.wikipedia.org/wiki/Precession_Electron_Diffraction19:12
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nmz787_i.title https://www.youtube.com/watch?v=MoUPJSaQdDc19:25
yoleauxSemGlu - a vacuum compatible, electron-cured adhesive. - YouTube19:25
nmz787_inow that is a cool video19:26
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kanzurefenn: i don't think you were really that surprised that steve wants to get ai first19:32
kanzureis that really surprising19:42
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nmz787here are some papers http://diyhpl.us/~nmz787/M&M%202015/72437/TOC.html20:11
nmz7871227 to be exact20:11
c0rw1nso much to learn, so little time ;_;20:12
nmz787voxa/mochii http://diyhpl.us/~nmz787/M&M%202015/7337/0009.pdf20:13
c0rw1n... but then if they're all like 2pgs long, that list would not take a lifetime to read :320:14
nmz787"This low voltage microscope has features that bring accessible and on-demand EM imaging into fields and laboratories where EM was previously hindered by form factor, complexity, and cost. Among these features are small size and light weight (0.25m tall, light enough to carry in a suitcase); user-friendly native wireless tablet interface; multi- and distance-user capabilities (connection to unlimited client nodes), exceedingly low power ...20:14
nmz787... consumption (by virtue of lowpower magnetic-electrostatic optics), and an integrated metal evaporator for easy sample preparation (only one pump-down cycle to image). We expect the cost to own and operate a MochiiTM microscope to be a fraction of the cost of typical EM’s with similar imaging performance due to its low power consumption, simple design, and commoditized user-replaceable consumables."20:15
nmz787see that one seems to actually be split over a couple at least http://diyhpl.us/~nmz787/M&M%202015/7337/0157.pdf20:16
nmz787http://diyhpl.us/~nmz787/M&M%202015/7337/1073.pdf20:18
nmz787"Democratizing the Micro-Scale: A Simplified, Miniaturized SEM for K-12 and Informal Student Scientists"20:18
nmz787they all went to Evergreen :O20:18
nmz787?20:19
c0rw1n( huh who what where ? )20:19
nmz7873/420:19
nmz787last one20:19
nmz787huh, and a HiveBio mention20:19
c0rw1nso that's at least 3 papers on the Mochii™ ?20:20
nmz787I think that is/was the seattle biohackerspace20:20
nmz787yeah20:20
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nmz787huh, LS Own is on hivebio.org/people/20:27
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xtalmathhow much does that mochii cost?20:38
nmz787supposedly $48k20:38
xtalmathI wonder how it works without vacuum?20:38
nmz787it has 2 vac pump20:39
nmz7871 turbo inside, and 1 rough outside20:39
xtalmathok20:39
xtalmathhow much vacuum is needed for SEM in fact? what level of vacuum did the first SEM's have?20:40
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nmz787they used higher accelerating voltages in the early days before lens design got better i guess20:41
nmz787but they had oil diffusion back then, which is just hot and oil can deposit into the sample chamber after a lot of use20:41
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xtalmathhttp://www.directorypatent.com/GB/511204-a.html21:03
xtalmathI wonder if something like kelvin water dropper + millikan experiment like combination could be used to build a "electron droplet" microscope in atmosphere... ( https://en.wikipedia.org/wiki/Kelvin_water_dropper , it amplifies the voltage difference, until a saturation point where the droplets bounce upwards and seek out the droplets of the other side...21:06
xtalmaththere is variations with a recirculating pump21:07
xtalmathmight be fun to make a slow droplet accelerator, and lets the droplets collide?21:19
xtalmathhow does an electron microscope work on insulating materials? http://www.toyo.co.jp/file/pdf/spm/files/agi/5991-0736EN.pdf21:57
xtalmathis that like pure reflection mode?21:58
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